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Heterologous biosynthesis of thaxtomin derivatives from modified tryptophans. i) The two NRPS genes required for thaxtomin biosynthesis in S. scabies were assembled into a synthetic operon and heterologously expressed in S. albus. Feeding of tryptophan analogues to this strain resulted in new thaxtomin D analogues. ii) The inclusion of the P450 TxtC into the pathway resulted in hydroxylated thaxtomin A analogues.
