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A synthetic pathway for biosynthesis of thaxtomin D derivatives directly from indole. The two NRPS genes required for thaxtomin biosynthesis in S. scabies were optimized into a synthetic operon with codon optimized TrpS genes from Salmonella and heterologously expressed in S. albus. Feeding of indole analogues to this strain resulted in thaxtomin D analogues being produced in vivo.
