Table 1.

Genetic association analyses of rs3931917 in a UK and a Spanish cohort of SSc patients via allelic testing^a

rs3131917	Minor allele	Minor allele frequency		Chi‐square	P corr b	OR (95% CI)
		Cases	Controls
Overall association analysis
UK, SSc+ vs. SSc–	T	0.48	0.46	1.16	0.28	1.06 (0.94–1.2)
Spanish, SSc+ vs. SSc–	G	0.48	0.51	3.6	0.05	0.9 (0.82–1)
Meta‐analysis					0.029	0.91
Subphenotype analysis
UK, anti–RNAP III+ vs. control	T	0.54	0.46	6.25	0.023	1.34 (1.06–1.7)
Spanish, PH+ vs. control	G	0.42	0.51	7.8	0.005	0.72 (0.57–0.9)
Spanish, PF+ vs. control	G	0.46	0.51	3.97	0.04	0.84 (0.72–0.99)

^aShown are chi‐square test values, corrected P (P _corr) values, and odds ratios (ORs) with 95% confidence intervals (95% CIs) for the genetic association of the rs3131917 single‐nucleotide polymorphism with systemic sclerosis (SSc) in a meta‐analysis of 2 independent cohorts (UK and Spanish), as well as for a subphenotype analysis of the association of rs3131917 with the anti–RNA polymerase III (anti–RNAP III) autoantibody, pulmonary hypertension (PH), and pulmonary fibrosis (PF). The minor allele and its frequencies in cases and controls are also shown. Genetic analyses were performed using Plink.

^b P _corr values for multiple comparisons were determined by permutation analysis.