FIG. 5.

(A) Killing of intracellular MRSA-MW2 in macrophages. MRSA-MW2 cells were exposed to RAW 264.7 macrophages, treated with test compounds 1–4 at 1× MIC and the killing of internalized bacteria was measured by CFU enumeration. Vancomycin (8 μg/ml) was used as a positive control and DMSO 0.1% as the negative control. Data represent the mean ± SEM (n = 3). ***p < 0.001, two-way analysis of variance with Bonfererroni post-test comparing DMSO control at 24 hr time point. (B) Killing of planktonic MRSA-MW2. MRSA-MW2 cells were exposed test compounds 1–4 at 1× MIC and the CFU was measured. CFU, colony forming unit.