Table 1.
Antibacterial Activity (μg/ml) of Compounds 1–4 Against ESKAPE Pathogens
| 1 | 2 | 3 | 4 | Vancomycin | Polymyxin B | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | |
| Staphylococcus aureus | 4 | 64 | 8 | >64 | 8 | >64 | 2 | 32 | 4.0 | 16 | >64 | >64 |
| Enterococcus faecium | 8 | >64 | 8 | >64 | 8 | >64 | 2 | >64 | 4.0 | 64 | >64 | >64 |
| Acinetobacter baumanii | 32 | >64 | >64 | >64 | >64 | >64 | 32 | >64 | >64 | >64 | 4 | 8 |
| Enterobacter aerogens | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | 8 | 8 |
| Klebsiella pneumoniae | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | 8 | 8 |
| Pseudomonas aeruginosa | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | 2 | 4 |
MIC, minimal inhibitory concentration; MBC, minimal bactericidal concentration.