Table 3.
Fractional Inhibitory Concentration Index of Compounds 1–4 Used in Paired Combinations with Each Other and with Antibiotics
| FICI | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Compound | Clinical antibiotics | |||||||||
| Compound | 1 | 2 | 3 | 4 | CIP | DOX | EMN | GMN | STN | VAN |
| 1 | 0.75 | 1.0 | 0.75 | 0.5 | 1.0 | 0.75 | 0.75 | 2.0 | 2.0 | |
| 2 | 0.75 | 1.0 | 0.75 | 0.5 | 1.0 | 1.0 | 1.0 | 0.625 | 1.0 | |
| 3 | 1.0 | 1.0 | 1.0 | 1.0 | 0.75 | 0.5 | 0.5 | 0.5 | 0.5 | |
| 4 | 0.75 | 0.75 | 1.0 | 0.5 | 0.5 | 0.75 | 1.0 | 1.0 | 1.0 | |
Synergy FICI ≤0.5, antagonism FICI >4.0, no interaction 0.5 > FICI ≤4.0.28
CIP, ciprofloxacin; DOX, doxycycline; EMN, erythromycin; GMN, gentamicin; STN, streptomycin; Van, vancomycin; FICI, fractional inhibitory concentration index.