Table I.
Endogenous and exogenous glycan tumor and blood group antigens with known or potential carbohydrate–carbohydrate interactions. The list is derived from the large IgM and IgG carbohydrate antibody responses observed upon vaccination of human patients using GVAX pancreas (a granulocyte macrophage colony-stimulating factor-modified whole-cell tumor vaccine) (Xia et al. 2016)
| Glycan tumor antigens | Structure | Graphical structure representation | CCI |
|---|---|---|---|
| Endogenous glycans | |||
| Tn | GalNAcα1-Ser/Thr |  |
Yes |
| STn | Neu5Acα2,6GalNAcα1-Ser/Thr |  |
Yes |
| Lewisx | Galβ1-4[Fucα1-3]GlcNAcβ1-3Galβ1-R |  |
Yes |
| Sialyl Lewisx | Neu5Acα2-3Galβ1-4[Fucα1-3]GlcNAcβ1-3Galβ1-R |  |
Not known |
| Lewisy | Fucα1-2Galβ1-4[Fucα1-3]GlcNAcβ1-3βGalβ1-R |  |
Yes |
| GD3 | Neu5Acα2-8Neu5Acα2-3Galβ1-4Glcβ1-Cer |  |
Not known |
| T | Galβ1-3GalNAcα1-Ser/Thr |  |
No |
| Exogenous glycans | |||
| Neu5Gc variant of GM3 | Neu5Gcα2-3Galβ1-4Glcβ1-Cer |  |
Highly likely |
| Neu5Gc variant sialyl α2,6LacNAc | Neu5Gcα2-6Galβ1-4GlcNAcβ1-R |  |
Likely |
| Neu5Gc variant sialyl α2,3LacNAc | Neu5Gcα2-3Galβ1-4GlcNAcβ1-R |  |
Likely |