Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 3;73(7):845–852. doi: 10.1093/gerona/glx249

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 1. — Genes up- and down-regulated by aging from 6 months to 24 months in rat kidney, liver, and gastrocnemius muscle, and the impact of RAD001 on the expression of these age-perturbed genes at 24 months. Rats aged 4.5 month and 22.5 months were treated with vehicle and rats aged 22.5 months were treated with RAD001 for 6 weeks, with a read-out at 6 and 24 months. Transcriptional profiling in the kidney, liver and gastrocnemius muscle was carried out by RNA-seq. Heat maps (A, B, C) depict genes that are differentially expressed between 6- and 24 month-old tissues (p < .05 adjusted for false discovery rate [FDR]) and the impact of RAD001 on the expression profile of these age-regulated genes. The blue hash (#) indicates genes that are significantly different between 6- and 24-month-old vehicle treated rats (p < .05 adjusted for FDR) and the red asterisk (*) indicates genes that are significantly different between 24-month-old vehicle treated and 24-month-old RAD001 treated rats (p < .05 adjusted for FDR). Standardized expression levels, from low to high, are colored from green to red: thus gene up-regulation is shown by a transition from green to red, and down regulation by a transition from red to green. In each heat map image, each column represents a single rat and each row represents a single gene. N = 8–10 rats per group.