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. 2018 Jan 3;73(7):845–852. doi: 10.1093/gerona/glx249

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© The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Functional annotation of gene pathways differentially regulated by age (6-months vs 24-months vehicle-treated groups) and by RAD001 (24-month vehicle vs 24-month RAD001-treated groups) in kidney, liver, and gastrocnemius (gastroc) muscle of rats. Boxes with a color transition from green to blue represent up-regulated pathways (AGE-UP or RAD-UP) with p < 10^–20 (green) – p < 10^–3 (blue). Boxes with a color transition from red to yellow represent down-regulated pathways (AGE-DW or RAD-DW) with p < 10^–20 (red) – p < 10^–3 (yellow). Numbers of genes that are regulated in either direction by age or RAD001 are indicated in brackets: eg, AGE-UP_Kidney (2641).