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. 2018 Jan 3;73(7):845–852. doi: 10.1093/gerona/glx249

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© The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Representative photomicrographs illustrating longitudinal sections of hematoxylin and eosin (H&E)-stained kidneys (cortex region) from a 6-month-old rat treated with vehicle (A), a 24-month-old rat treated with vehicle (B) and a 24-month-old rat treated with RAD001 (C). Asterisks (*) in panel B indicate dilated renal tubules in the kidney from a 24-month-old rat treated with vehicle. Scale bars, 100 μm. (D) Graphical summary of semiquantitative histopathology scores. Data are mean ± SD. ****p ≤ .0001, **p≤ = .01. N = 8–10 rats per group.