Figure 4.

Fasting causes regional increases in brain lactate. (A) Fasting did not induce changes in hexose phosphate, hexose bisphosphate, ATP, or ADP compared to random fed mice. (B) Fasting induced increases in lactate in the cortex and hippocampus without changing levels in other brain regions. N = 5. (C) After glucose enters a cell it can be metabolized through glycolysis (left) or the pentose phosphate pathway (right). Enzymes assessed are in green ovals. Metabolites measured are in bold. G6PD = glucose-6-phosphate dehydrogenase, PGI = phosphoglucoisomerase, PFK = phosphofructokinase.