Table 3.
Confirmation of SNPs for BMI and educational attainment fulfilling the p-value treshold p < 9.69 × 10−5.
| SNP | Region | Mapped Gene | Effect allele | P-values |
|||
|---|---|---|---|---|---|---|---|
| BMI – Discovery | BMI - Confirmation | Educational Attainment - Discovery | Educational Attainment - Confirmation | ||||
| rs1260326 | 2p23.3 | GCKR | A | 9.2 × 10−5 | n.s. | ||
| rs7570971 | 2q21.3 | RAB3GAP1 | A | 1.5 × 10−6 | n.s. | ||
| rs1047891 | 2q34 | CPS1 | A | 8.1 × 10−5 | 4.7 × 10−3 | ||
| rs715 | 2q34 | CPS1 | T | 7.1 × 10−6 | 4.7 × 10−3 | ||
| rs10513801 | 3q27.2 | ETV5 | T | 1.1 × 10−21 | 3.4 × 10−3 | 2.0 × 10−5 | 1.3 × 10−2 |
| rs12654264 | 5q13.3 | HMGCR | T | 1.8 × 10−8 | 8.3 × 10−9 | ||
| rs3184504 | 12q24.12 | SH2B3 | T | 9.3 × 10−6 | n.s. | ||
| rs2066938 | 12q24.31 | UNC119B | A | 4.4 × 10−6 | n.s. | ||
| rs2014355 | 12q24.31 | ACADS | T | 5.0 × 10−6 | n.s. | ||
| rs3916 | 12q24.31 | ACADS | G | 3.2 × 10−6 | n.s. | ||
| rs12446492 | 16p12.3 | PDILT | A | 3.0 × 10−5 | n.s. | ||
| rs7200543 | 16p13.11 | PDXDC1 | A | 1.0 × 10−5 | 4.2 × 10−5 | ||
| rs11075253 | 16p13.11 | PDXDC1, NTAN1 | A | 4.6 × 10−5 | 7.0 × 10−4 | ||
| rs8056893 | 16q22.1 | SLC7A6 | A | 3.1 × 10−5 | 4.5 × 10−3 | ||
| rs2863979 | 16q22.1 | SLC7A6 | A | 2.7 × 10−5 | 3.6 × 10−3 | ||
| rs9916302 | 17q12 | FBXL20 | T | 1.9 × 10−5 | 3.9 × 10−2 | ||
| rs7219014 | 17q12 | CDK12 | A | 1.1 × 10−5 | 1.6 × 10−2 | ||
Horizontal lines separate chromosomal regions of 1 Mb.
Bold values indicate significant values in the discovery data sets upon correction for 14 traits and 516 SNPs (p < 6.92 × 10−6).
BMI: Body mass index; n.s: p ≥ 0.05.
The effect allele direction was consistent in discovery and confirmatory data for all replicated SNPs.