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. 2018 Apr 18;12:39–47. doi: 10.1016/j.molmet.2018.04.004

Figure 3.

Figure 3

Effect of resveratrol (RSV) on ex vivo and in vivo mitochondrial function. After 30 days of resveratrol and placebo, a muscle biopsy specimen was obtained from the vastus lateralis muscle. Part of the specimen was used for evaluation of ex vivo mitochondrial function (n = 10). A: ADP stimulated respiration (state 3) upon a lipid-like substrate and upon parallel electron input into complex I and II. B: Maximally uncoupled respiration upon FCCP (carbonyl cyanide p-(trifluoro-methoxy)-phenylhydrazone). C: the protein content of the individual complexes of the electron transport chain is quantified by western blotting in vastus lateralis muscle. An antibody cocktail that detects all five complexes was used (n = 10). D: in vivo mitochondrial function expressed as PCr half-time (n = 9). Data are presented as individual data points, means ± SEM. *P < 0.05 compared to placebo. M, malate; O, octanoyl-carnitine; G, glutamate; S, succinate; ww, wet weight; OXPHOS, oxidative phosphorylation; PCr, phosphocreatine recovery.