Fig. 3.

Virus and cell dynamics for: (a)–(d) innate immune responses to acute virus infection given by Eqs. (6), (7), (8), (9), (10), (11), (12), (13), (14), (15), (16), (17), (18), (19), (20), (21), parameters $\left(\beta ,\delta ,p,c,\alpha ,k,\tau ,d_F,{\mathit{\varepsilon }}_1,{\mathit{\varepsilon }}_2\right)=\left(4.2\times {10}^{-6},\mathrm{7,0.32},13.4,\mathrm{1,26.6},0.5,5.2,3.5\times {10}^{-6},3\times {10}^{-7}\right)$ and initial conditions $\left(T,E,I,V,F\right)\left(0\right)=\left(4\times {10}^8,\mathrm{0,0},{10}^{-2},1\right)$ as in (Baccam et al., 2006, Pawelek et al., 2012); (b)–(e) cellular immune responses to chronic virus infection given by Eq. (23) for parameters $\left(s,d,\beta ,\delta ,p,c,\mu ,d_E\right)=\left({10}^4,0.01,{10}^{-6},\mathrm{1,1200,23}\right)$, $\left(s_E,\alpha ,\mu ,d_E\right)=\left(\mathrm{0,0,0,0}\right)$ (solid lines), $\left(s_E,\alpha ,\mu ,d_E\right)=\left(300,{10}^{-5},\mathrm{1,0.5}\right)$ (dashed lines), and initial conditions $\left(T,I,V,E\right)\left(0\right)=\left({10}^6,\mathrm{0,100,10}\right)$; (c)–(f) humoral immune responses to chronic virus infection given by Eq. (25) for parameters $\left(s,d,\beta ,\delta ,p,c\right)=\left({10}^4,0.01,{10}^{-6},\mathrm{1,1200,23}\right)$, $\left(\alpha ,c_A,d_A,s_A\right)=\left(\mathrm{0,0,0,0}\right)$ (solid lines), $\left(\alpha ,c_A,d_A,s_A\right)=\left({10}^{-6},\mathrm{92,0.07},1\right)$ (dashed lines) and initial conditions $\left(T,I,V,A\right)\left(0\right)=\left({10}^6,\mathrm{0,100,14}\right)$.