Table 1.

PTPN22 and models of autoimmunity

Model	PTPN22 status	Genetic background	Impact on disease	Immunological features	References
EAE	KO	C57Bl/6	Protection	Protection involves increased Tregs	46
Colitis	KO	C57Bl/6	Exacerbated	Increased T‐cell expansion	17
Lupus like disease	KO + CD45 E613R	C57Bl/6	Exacerbated	Enhanced effector/memory T‐cells	40
Diabetes	Knock‐down	NOD	Protection	Protection involves increased Tregs	43
Diabetes	Overexpression	NOD	Protection	Reduced Th1 functionality	44
Diabetes	R619W KI (CRISPR)	NOD	Exacerbated	Not assessed	42
Diabetes RIP‐LCMV	KO	C57Bl/6	Exacerbated	Increased T effector function	47
Systemic autoimmunity	R619W (and STZ diabetes)	C57Bl/6x129/Sv	Exacerbated	B‐cell restricted R619W expression sufficient to induce autoimmunity	41
SKG arthritis	KO	SKG	Protection	Biasing of Th17 differentiation toward Th1/Treg	45
SKG arthritis	Transgenic R620W	SKG	No difference	–	50
KBxN arthritis	KO	C57Bl/6	Exacerbated	Increased T follicular helper cells	32
KBxN arthritis	KO	C57Bl/6	Protected	Reduced neutrophil activation	6