Figure 4.

Neither insulin promoter‐driven hen egg lysozyme transgene (insHEL) nor thyroglobulin promoter‐driven hen egg lysozyme transgene (thyroHEL) mediates deletion when only the bone marrow‐derived antigen presenting cells (BM‐APCs) are transgenic. Irradiated non‐transgenic (Non‐Tg) hosts (CD45^2/2) were reconstituted with Non‐Tg, insHEL or thyroHEL (CD45^1/1) BM mixed with 3A9 (CD45^1/2) BM at a ratio of 9 : 1. Six weeks later, CD45^1/2 TCR^3A9+ Foxp3^– thymocytes were analysed for CD4/CD8 phenotype (left) and the CD4SP cell percentage was determined (right). Each symbol represents one mouse; each line shows the group mean.