Table 2.
Change in clinical and functional signs of atopic dermatitis at the end of the maintenance phase (day 24)
| Evaluator | Assessmenta | TCS alone study arm (n = 39) | TCS + MDREC study arm (n = 43) | P valueb |
|---|---|---|---|---|
| Investigator | L-SCORAD index | − 4.74 ± 3.42 | − 6.05 ± 2.95 | 0.0056 |
| L-IGA score | − 1.41 ± 1.21 | − 1.84 ± 1.19 | 0.0195 | |
| Subjects | Pruritus intensity | − 1.81 ± 2.41 | − 2.81 ± 2.68 | 0.0014 |
| L-PO-SCORAD index | − 2.85 ± 3.40 | − 3.81 ± 3.57 | 0.0577 | |
| L-PGA score | ||||
| Worse (score = 0) | 2 (5.3%) | 2 (4.8%) | 0.0002 | |
| No change (score = 1) | 7 (18.4%) | 1 (2.4%) | ||
| Slight improvement (score = 2) | 18 (47.4%) | 19 (45.2%) | ||
| Marked improvement (score = 3) | 8 (21.1%) | 9 (21.4%) | ||
| Total resolution (score = 4) | 3 (7.9%) | 11 (26.2%) | ||
Values in table are presented as the number of subjects with the percentage in parenthesis or as the mean ± SD
aL-PGA (local patient’s global assessment) was scored on a 5-point scale from 0 for worse lesions to 4 for total resolution of lesions. For explanation of all other indexes/scores, see footnotes to Table 1
bP values were determined by Wilcoxon sign-rank test