Table 5.

Scenario analyses inputs and results for herpes zoster cases avoided comparing vaccination with Recombinant Zoster Vaccine and Varicella Vaccine Live

Scenario	Second-dose compliance with RZV vaccination	Initial efficacy of RZV (one dose) against HZ	Initial efficacy of RZV (two doses) against HZ	Waning of RZV efficacy (one dose)	Waning of RZV efficacy (two doses)	Number of HZ cases avoided with RZV compared to VVL
Scenario 1	Upper bound	Upper bound	Upper bound	Lower bound	Lower bound	4,342,890
Scenario 2	Base	Base	Upper bound	Base	Lower bound	4,151,864
Base case	Base	Base	Base	Base	Base	2,523,687
Scenario 3	Base	Base	Lower bound	Base	Upper bound	1,180,198
Scenario 4	Lower bound	Lower bound	Lower bound	Upper bound	Upper bound	694,132

HZ herpes zoster, RZV Recombinant Zoster Vaccine, VVL Varicella Vaccine Live