Table 3.
UAS7 at first and second cycles of omalizumab administration
Omalizumab administration | Initial therapy | Retreatment therapy | p value |
---|---|---|---|
Patients, n (%) | 18 (100) | 3 (17.6) | – |
7-day Urticaria Activity Score (UAS7), mean, standard deviation (range) | |||
Baseline | 27.3 ± 7.4 (15–38) | 19.3 ± 4.9 (16–25) | 0.091 |
Week 1 | 18.1 ± 7.4 (3–38) | 2.3 ± 2.5 (0–5) | 0.002 |
Week 4 | 16.1 ± 10.5 (0–36) | 1.3 ± 1.2 (0–2) | 0.028 |
Week 12 | 10.2 ± 12.6 (0–39) | 0.7 ± 1.2 (0–2) | 0.215 |
Week 16 | 8.3 ± 10.6 (0–33) | 1.7 ± 1.5 (0–3) | 0.306 |
Week 20 | 6.6 ± 8.5 (0–22) | 0 | 0.207 |
Week 24 | 8.3 ± 12.4 (0–35) | – | – |
Drop out, n (%) | 1 (5.6) | 0 | – |
Response based on UAS7 at end of treatment, n (%)a | |||
Complete (UAS7 = 0) | 10 (58.8) | 3 (100) | – |
Good (1 ≤ UAS7 ≤ 6) | 1 (5.9) | 0 | – |
Partial (6 < UAS7 < UAS7 at baseline) | 4 (23.5) | 0 | – |
No response (UAS7 ≥ UAS7 at baseline) | 2 (11.8) | 0 | – |
a17 patients completed the treatment