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. 2018 Jun 1;8(6):50. doi: 10.1038/s41408-018-0090-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Association of FANC mutations with recurrent somatic AML mutations and cytogenetics in the Australian AML Cohort. The columns in the figure represent each patient in the Australian AML cohort (n = 131). The first row in the figure represents the 22 FANC genes as a group. The subsequent rows represent individual FANC genes, AML recurrently mutated genes, karyotype and cytogenetic characteristics. Patients carrying one or more FANC mutations (n = 44) are represented with red boxes. Black boxes indicate patients carrying a D-C mutation for the specific FANC gene. Patients with specific AML mutations are represented with blue boxes. Patients with normal, abnormal (1 or 2 abnormalities) and complex (3 or more abnormalities) karyotypes are represented with green boxes. Patients with specific karyotypic abnormalities are represented by orange boxes. Del7/7q is under-represented (blue highlight) in the FANC-mutant AML patient group (P = 0.028). b D-C mutations present in the Australian AML cohort. Frequency of each D-C mutation is presented for the Australian AML and control cohorts, and for the ExAc (non-Finish European) database