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. 2018 Jun 14;8:9159. doi: 10.1038/s41598-018-27069-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of the myometrial cell model⁴⁹. Left: The electrochemical and chemomechanical subsystems are coupled via the intracellular calcium concentration. The arrows indicate the direction of influence of the coupled systems. Right: Model components of 7 inward membrane channels (red arrows), 5 outward membrane channels (blue arrows), a calcium membrane pump, a Na-K-Cl symporter, 2 membrane ion exchangers, a SERCA pump (I_up), an SR transfer current (I_tr) and an SR release current (I_rel) controlled by the ryanodine receptors (RyR) were shown. The colours in the flow diagram match their respective systems in the cell diagram.