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. 2018 Jun 14;8:9159. doi: 10.1038/s41598-018-27069-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bursting electrical activity of the model and comparison with experimental data. (A) Simulated bursting action A Inset: experimental data of bursting AP from Bengtsson et al.²². (B) Simulated staircase-like calcium transient generated by bursting APs. B Inset (centre): the stimulus applied during this simulation, −0.4 pA pF⁻¹ for a duration of 5 s. B Inset (right): experimental data from Shmygol et al.²⁸. (C) Computed results of four principal currents: L-type calcium, sodium and voltage gated potassium currents (I_K1 and I_K2) during the time course of bursting APs. (D) Simulated total contractile force of the cell model. D Inset: experimental data from Zafrah and Alotaibi³².