Figure 7.

The influence of 10 µM of nifedipine on the total calcium current and Ca²⁺ transients. A voltage clamp from −80 to 0 mV was applied to the cell membrane for 10 seconds. (A,B) The membrane voltage response to the control and nifedipine conditions respectively, showing a drop of approximately 100 times in the maximum current value. B (inset): Experimental data from Wray et al. demonstrating the drop in current due to the action of nifedipine⁴². Both simulations (C) and experiments (Wray et al.⁴²) (D) suggest that in the presence of nifedipine, applying a voltage across the membrane prevents an influx of calcium into the cell.