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. 2018 Jun 14;8:9158. doi: 10.1038/s41598-018-26746-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NXT inhibits lipid accumulation, reduces total glomerular area and VEGFA expression in db/db mouse kidneys. At the end of treatment as indicated in Fig. 1, mouse kidneys were removed and used to prepare frozen cross sections or total proteins. (a) The representative photos of kidneys (upper left panel), ratio of kidney weight to bodyweight (the right panel) and images of Oil Red O staining of cross sections (lower left panel); (b,c) kidney frozen cross sections were used to detect morphological changes of glomerulus by HE staining (b) followed by quantitation of the glomerular area (c). ^*p < 0.05 vs. wild type group; ^#p < 0.05 vs. db/db control group (n ≥ 5); (d,e) VEGFA expression was determined by immunohistochemical staining with kidney frozen cross sections (d), and by Western blot with total cellular proteins extracted from a piece of kidney (e), respectively. *p < 0.05 vs. db/db control group (n ≥ 5).