Table 1.
Genes upregulated by E2 in prepubertal grass carp pituitary cells.
| Gene | Description | Fold change | GO-biological process |
|---|---|---|---|
| DERL3 | Derlin-3 | 10.21 | Degradate misfolded glycoproteins |
| PNGase F | Peptide-N4-N-acetyl-beta-d-glucosaminyl asparagine amidase F | 3.86 | Degradate misfolded glycoproteins |
| LHβ | Luteinizing hormone beta subunit | 5.19 | Reproduction |
| FSHβ | Follicle-stimulating hormone beta subunit | 1.82 | Reproduction |
| DRD2 | Dopamine D2 receptor (GPCR) | 1.79 | Reproduction |
| GREB1 | Growth regulation by estrogen in breast cancer 1 | 5.78 | Estrogen receptor binding |
| RNF4 | E3 ubiquitin-protein ligase RNF4 | 1.73 | Estrogen receptor binding |
| PGR | Progesterone receptor 1 | 1.71 | Steroid binding |
| APOC | Apolipoprotein C Ia | 2.25 | Cholesterol metabolic process |
| NUPR1 | Nuclear protein 1 | 2.23 | Male gonad development |
| NR5A1 | Nuclear receptor subfamily 5 group A (SF-1) | 2.34 | Male gonad development |
| DRC7 | Dynein regulatory complex subunit 7 | 1.68 | Spermatogenesis |
| PLP1 | Proteolipid protein 1b | 6.3 | Central nervous system development |
| HAPLN3 | Hyaluronan and proteoglycan link protein 3 | 4.43 | Central nervous system development |
| NRP1 | Neuropilin-1a isoform 1 precursor | 1.83 | Central nervous system development |
| S100B | S100 calcium binding protein, beta (neural) | 2.1 | Central nervous system development |
| LRRC4 | Leucine-rich repeat-containing protein 4 | 2.08 | Synaptic adhesion protein |
| SYT13 | Synaptotagmin-13 precursor | 2.19 | Synaptic vesicle transport |
| OCLN | Occludin-like | 2.03 | Cell–cell junction organization |
| FBN1 | Fibrillin-1-like | 2.61 | Cell proliferation |
| PLAU | Plasminogen activator PLAU | 3.19 | Cell proliferation |
| FGFR4 | Fibroblast growth factor receptor 4 | 1.63 | Cell proliferation |
| HYAL2 | Hyaluronidase-2-like | 1.71 | Cellular response to FGF stimulus |
| PPT2 | Lysosomal thioesterase PPT2-like | 1.61 | Fatty-acyl-CoA biosynthetic process |
| TRDMT1 | tRNA (cytosine-5-)-methyltransferase | 1.77 | Methyltransferase |
| TMEM53 | Transmembrane protein 53 | 1.81 | Integral component of membrane |
| FAM222A | Family with sequence similarity 222, member A | 1.73 | Protein dimerization activity |
| TMTC2 | Transmembrane and TPR repeat-containing protein 2 | 1.67 | Calcium ion homeostasis |