Table 2.
Genes downregulated by E2 in prepubertal grass carp pituitary cells.
| Name | Description | Fold change | GO-molecular function |
|---|---|---|---|
| RYR3 | Ryanodine receptor 3 | 0.39 | Calcium ion binding |
| ATP2B | Membrane calcium-transporting ATPase 2 | 0.56 | Calcium-transporting |
| CELSR1 | Cadherin EGF LAG seven-pass G-type receptor 1 | 0.54 | Calcium ion binding |
| LDLR | Low-density lipoprotein receptor-like | 0.60 | Calcium ion binding |
| GRN | Granulin | 0.50 | Response to estradiol |
| DHCR24 | 24-dehydrocholesterol reductase | 0.60 | Steroid metabolic process |
| LSS | Lanosterol synthase | 0.60 | Steroid biosynthetic process |
| NSDHL | Sterol-4-alpha-carboxylate 3-dehydrogenase | 0.59 | Steroid dehydrogenase activity |
| SCRIB | Protein scribble homolog isoform X8 | 0.59 | GTPase activator activity |
| SGSM1 | Small G protein signaling modulator 1 | 0.52 | GTPase activator activity |
| FAM13A | Protein FAM13A isoform X2 | 0.55 | GTPase activator activity |
| SFRP2 | Secreted frizzled-related protein 2 | 0.56 | Wnt-protein binding |
| CTNNB1 | Catenin beta-1-like | 0.56 | Wnt signaling pathway |
| CD2AP | CD2-associated protein | 0.57 | Beta-catenin binding |
| ZNFX1 | NFX1-type zinc finger-containing protein 1-like | 0.59 | Transcription factor activity |
| TSC22D3 | TSC22 domain family protein 3 | 0.59 | Transcription factor activity |
| TIMP3 | Metalloproteinase inhibitor 3-like | 0.58 | Metalloendopeptidase inhibitor |
| TIMP2 | Tissue inhibitor of metalloproteinase 2 | 0.59 | Metalloendopeptidase inhibitor |
| BRD4 | Bromodomain-containing protein 4 | 0.59 | NF-kappa B signaling |
| JIP2 | c-Jun-amino-terminal kinase-interacting protein | 0.58 | JNK/MAPK cascade |
| PHIP | PH-interacting protein isoform X2 | 0.60 | Insulin receptor binding |
| CRIM1 | Cysteine rich transmembrane BMP regulator 1 | 0.58 | IGF binding |
| IGF1R | IGF-I receptor subtype a | 0.58 | IGF binding |
| COL5AS | Collagen alpha-1 (V) chain | 0.59 | Heparin/integrin binding |
| PTPRF | Receptor-type tyrosine-protein phosphatase F | 0.58 | Heparin binding |
| NAV2 | Neuron navigator 2 isoform X1 | 0.58 | Heparin binding |
| ANK | Ankyrin-2-like | 0.59 | ATPase binding |
| ABCA3 | ATP-binding cassette sub-family A member 3 | 0.55 | ATPase activity |
| RAPGEF2 | Rap guanine nucleotide exchange factor 2 | 0.60 | Adrenergic receptor binding |
| FN1 | Fn1 protein | 0.56 | Adrenal gland development |
| TBX20 | T-box transcription factor TBX20 | 0.53 | DNA binding |
| RFX1 | MHC class II regulatory factor RFX1 | 0.43 | DNA binding |
| ADARB | Adenosine deaminase, RNA-specific, B1 | 0.58 | RNA binding |
| FAM120C | Family with sequence similarity 120C | 0.60 | RNA binding |
| SSTR3 | Somatostatin receptor type 3 | 0.60 | Neuropeptide binding |
| MAP1 | Microtubule-associated protein 1A-like | 0.59 | Ubiquitin protein ligase binding |