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. 2018 Jun 8;8:209. doi: 10.3389/fonc.2018.00209

Table 1.

Characteristics of the study population (N = 193).

Patients Case subjects,
N = 93
Control subjects,
N = 100

Breast cancer n(%, 95% CI) n(%, 95% CI)
Age (years)
30–39 11 (11.83, 21.50–22.85) 9 (9.00, 0.00–19.36)
40–49 34 (36.56, 26.88–47.58) 37 (37.00, 27.00–47.36)
50–59 26 (27.96, 18.28–38.98) 36 (36.00, 26.00–46.36)
60–69 15 (16.13, 64.52–27.15) 17 (17.00, 7.00–27.36)
70+ 7 (7.53, 0.00–18.55) 1 (1.00, 0.00–1.36)
Histologic type
Ductal carcinoma 80 (86.02, 80.65–93.30) 84 (84.00, 78.00–91.42)
Lobular carcinoma 10 (10.75, 4.30–17.32) 16 (16.00, 10.00–23.42)
Combined ductal/
lobular carcinoma
2 (2.15, 0.00–8.72)
Metaplastic carcinoma 1 (1.08, 0.00–7.64)
Year at diagnosis n(%) n(%)
1998–2000 4 (4.30) 19 (19.00)
2001–2003 10 (10.75) 22 (22.00)
2004–2006 17 (18.28) 21 (21.00)
2007–2009 31 (33.33) 17 (17.00)
2010–2012 31 (33.33) 21 (21.00)

CIN3+ n(%, 95% CI)

Age (years)
<30 4 (4.30, 0.00–15.52)
30–39 27 (29.03, 19.35–40.25)
40–49 24 (25.80, 16.13–37.02)
50–59 25 (26.88, 17.20–38.10)
60+ 13 (13.98, 4.30–25.19)
Histologic type
CIN3 34 (0.37, 0.27–0.48)
Squamous cell
carcinoma in situ
31 (0.33, 0.24–0.45)
Adenocarcinoma in situ 3 (0.03, 0.00–0.15)
Squamous cell carcinoma 20 (0.22, 0.12–0.33)
Adenocarcinoma 5 (0.05, 0.00–0.17)
Year at diagnosis n(%)
1998–2000 28 (30.11)
2001–2003 30 (32.26)
2004–2006 18 (19.35)
2007–2009 12 (12.90)
2010–2012 5 (5.38)