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. 2018 Jun 8;12:392. doi: 10.3389/fnins.2018.00392

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Copyright © 2018 Che, Fang, Si, Wang, Hu, Reis and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms involved in the cytoprotective effect of carbon monoxide (CO) after TBI. The CO produced by heme oxygenase (HO) isozymes participated in the process of antioxidantien, anti-inflammation, anti-apoptosis, and vasodilatation.