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. 2018 Jun 8;8:214. doi: 10.3389/fonc.2018.00214

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Copyright © 2018 Meléndez-Rodríguez, Roche, Sanchez-Prieto and Aragones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypoxia-inducible factor (HIF)2α-dependent pathways that sustain clear cell renal cell carcinoma (ccRCC) growth. The figure represents those target genes primarily controlled by HIF2α and those biological actions executed by these genes, such as tumor angiogenesis, cell autonomous proliferation, potentiation of glycolysis and pentose phosphate pathway (PPP), resistance to oxidative damage, endoplasmic reticulum (ER) stress, as well as metastasis.