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. 2018 Jun 14;8:9105. doi: 10.1038/s41598-018-27358-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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G6PD is altered in human HCC. (a) G6PD mRNA levels in tumors from liver cancer patients. Normalized mRNA levels from benign livers (n = 50) and liver tumors (n = 377) quantified using RNA-seq were queried from The Cancer Genome Atlas. Significance was determined using Welch’s T-Test function in R (p-value = 1.082346e-40). (b) Dot-plot of G6PD mRNA levels in different tumor grades (ANOVA, P-value = 6.79e-07). Comparison between means using Tukey Honest Significance Test in R revealed significant difference in G6PD mRNA levels with increasing tumor grade (Supplementary Table 1). (c) Kaplan-Meier curve of G6PD overall survival in liver cancer patients (n = 318, patients with missing data or surviving past 5 years were removed from the analysis). Patients were stratified by high expression (top 50th percentile), and low expression (bottom 50th percentile). (d) Kaplan-Meier curve of tumor recurrence in liver cancer patients with respect to G6PD levels. Analysis was done as described in (c).