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. 2018 Jun 14;8:9151. doi: 10.1038/s41598-018-27386-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Temporal development of biomarkers. Estimated marginal means are calculated by general linear models (two-way ANOVA with repeated measurements design) and p-values were adjusted according to Benjamini and Hochberg. Data is given as estimated marginal mean and 95% confidence interval, and confidence intervals from stress patients are light grey shaded, whereas confidence intervals from controls are dark grey shaded. (b) Variation in cortisol day profiles at baseline (light grey) and before follow-up examinations (dark grey) within the stress (top) and the control cohort (bottom). AUC_g, area under the curve with respect to ground; AUC_i, cortisol awakening response – area under the curve with respect to increase; MPO, plasma myeloperoxidase; IL6, interleukin 6; n.s., not significant; ***p_BH < 0.001; *p_BH < 0.05.