Figure 5.

E/LPS injury impairs RSV–dependent induction of type I IFN. ELISA analysis for IFN-α and IFN-β was performed on BAL fluid from PBS + Mock–, E/LPS + Mock–, PBS + RSV–, and E/LPS + RSV–infected mice at Days 0, 1, 4, 7, 10, and 14 postinfection. RSV infection in the E/LPS-injured mice significantly attenuated the BAL levels of (A) IFN-α and (B) IFN-β when compared with PBS-treated control mice; n = 6 mice per group; data reported as mean (±SEM); ^†P < 0.05, different from PBS + mock–infected group; ^#P < 0.05, different from E/LPS + mock–infected group; *P < 0.05, different from PBS group.