FIG 6.

2-AAA-fed mice develop CMT2-like phenotypes similar to those of Dhtkd1^−/− mice. (A and B) Tests of general motor performance using an accelerating rotarod (A) and a treadmill (B) (n = 10 mice per group). (C) Electron micrographs of sciatic nerves in mice. Scale bars, 10 μm (top panel) and 2 μm (middle and bottom panels). (D) Real-time PCR analysis of the expression levels of central myelin genes, including Gjb1, Mpz, Mbp, PMP22, Prx, and Srebp2, in sciatic nerves. (E) Western blot analysis of P₀ and MBP protein levels in sciatic nerves. A Student two-sided t test was used for data in panels A, B, and D, and values are shown as means ± SD. *, P < 0.05.