TABLE 3.
Pathological findings for the PA mutant recombinant viruses in mice
| Virus | MLD50 (PFU) | % body wt loss (dpi)a | MDDb |
|---|---|---|---|
| rVc_BR60 | 104.4 | 21.73 (5) | 6 |
| rVc_BR60PA:K338R | 103.5 | 24.21 (6) | 7.2 ± 0.45 |
| rVc_BR60/WI01PA | >106 | 9.9 ± 3.97 (7) | ND |
| rVc_BR60/WI01PA:K338R | 105.5 | 24.97 (7) | 6.4 ± 1.14 |
| rYm_WI01 | >106 | 3.31 ± 1.52 (4) | ND |
| rYm_WI01PA:K338R | 105.6 | 20.22 ± 3.74 (5) | 7.4 ± 3.71 |
| rYm_WI01/BR60PA | >106 | 4.05 ± 2.43 (4) | ND |
| rYm_WI01/BR60PA:K338R | >106 | 3.27 ± 2.66 (8) | ND |
a
The mean maximum body weight loss of the mice infected with 106 PFU during 14 days postinfection (dpi) is indicated with standard deviation (SD).
b
The mean day of death (MDD) is indicated with SD, based on the survival rates of the mice infected with 106 PFU. ND, not determined.