FIG 5.

Magnitudes of heterologous tier 2 NAb activities in purified IgGs elicited in vaccinated guinea pigs. Purified polyclonal IgGs from vaccinated guinea pigs were evaluated against select tier 2 pseudoviruses and MuLV (negative control) at week 120 against the full tier 2 global panel (A) and at weeks 16, 78, 138, and 200 against select tier 2 viruses in the global panel (B). Horizontal black lines indicate mean titers, and gray dots indicate responses below the limit of detection of the assay. Red, blue, and black dots represent responses that were both detectable and greater than the value for the MuLV control. Each dot represents the result for a single guinea pig, colored according to vaccination regimen. In the C97 vaccination group, one guinea pig died at week 134 and one at week 177 due to age. Horizontal brackets denote statistically significantly different results (P < 0.05, Student's t test).