FIG 1.
BHV-1 UL49.5 predicted amino acid sequence and conserved cysteine residues between the gN and gM homologs of alphaherpesviruses. (A) Predicted amino acid sequences of the BHV-1 UL49.5 open reading frame (ORF). Signal sequence and luminal (ecto), transmembrane, and cytoplasmic tail domains are shown; the two cysteine residues C42 and C78 are italicized. (B) Alignment of predicted amino acid sequences of BHV-1, PRV, EHV-1, and HSV-1 UL49.5/gN homologs. Note that C42 (boxed) is conserved in all four gN homologs and that C78 is conserved in BHV-1, PRV, and HSV-1 but not in EHV-1. (C) Alignment of predicted amino acid sequences of BHV-1, PRV, EHV-1, and HSV-1 gM homologs. Cysteines (C) that are not conserved are in bold. Conserved cysteines are boxed. Asterisks (*) indicate positions which have a single, fully conserved residue; colons (:) indicate conservation between groups of strongly similar properties; periods (.) indicate conservation between groups of weakly similar properties.