FIG 7.

Time course of seroconversion, viremia, and fecal shedding in SPF rabbits inoculated with various virus mixtures. (A to C) Rabbits inoculated with only swine HEV (strain CHN-SD-sHEV), MAb 1E4, and normal mouse IgG; (D to F) rabbits inoculated with virus mixed separately with MAbs 2C7, 1B5, and 2G9; (G) rabbits inoculated with virus preincubated with HEV-infected serum; (H) rabbits inoculated with PBS only. Serum and fecal samples were collected before inoculation and at different weeks postinoculation. The dotted line represents the cutoff value of 0.29 of indirect ELISA. +/−, positive or negative HEV RNA in fecal or serum samples.