TABLE 4.

Comparison of novel MERS-related CoV genomic features and amino acid identities to other lineage C BetaCoVs with complete genome

Feature	% Nucleotide or amino acid identityf
	MERS-CoV	Bat MERS-related CoVa	HKU4b	HKU5c	HeCoV-1d	Within 845 and 422e
Genome	75.3	74.7–81.2	70.7–70.9	70.6–71.0	70.0–70.4	88.1
ADRP	70.6	69.5–85.1	56.7–57.8	55.9–59.0	66.0–66.5	91.0
3CLpro	89.2–89.9	89.5–95.1	78.8–79.7	83.3–84.0	81.7–82.0	97.7
RdRp	94.4–94.9	95.0–97.0	89.0–89.3	92.2–92.8	88.8–89.0	98.6
Hel, NTPase	94.8–95.2	95.0–98.3	93.1–93.8	94.5–95.3	92.0–92.5	99.5
ExoN	94.5–95.0	94.5–96.9	84.7–85.9	91.2–92.0	89.7–90.3	98.7
NendoU	87.8–88.0	88.0–90.1	75.1–77.4	80.5–81.2	85.4–86.3	97.1
OMT	88.4–88.7	88.4–95.7	84.6	86.1–86.4	85.8–87.7	96.7
S	64.7–64.9	43.3–68.3	65.0–67.8	58.5–60.6	45.9–46.1	76.2
S-RBDg	61.9–63.6	34.6–57.6	71.3–72.9	56.7–60.3	41.1	83.8
E	80.5–82.9	82.9–85.4	79.7–72.0	69.5	74.4–75.6	90.2
M	86.2–88.5	88.1–92.7	78.4–80.3	80.7–82.6	80.3–81.2	95.4
N	79.0–79.1	78.8–90.5	73.1–73.8	71.1–71.5	72.2–73.3	85.6
ORF3	41.6–45.0	44.6–57.0	31.9–40.0	37.3–45.8	20.6–23.0	50.0
ORF4a	51.1–52.1	54.3–71.3	44.7	40.9–47.3	43.2	80.9
ORF4b	38.7–43.3	41.3–66.5	30.3–31.6	26.5–34.8	39.6–46.3	58.8
ORF5	66.1–67.0	65.2–78.9	43.1–45.8	55.7–56.6	52.3–53.3	89.0

^aSequences accession numbers KJ473821, KX574227, and KC869678.

^bSequences accession numbers NC_009019, EF065506, EF065507, EF065508, and KJ473822.

^cSequences accession numbers NC_009020, EF065510, EF065511, EF065512, KJ473820.

^dSequences accession numbers KC545383 and KC545386.

^e845 and 422 are abbreviations for BtCoV/Ii/GD/2013-845 and BtCoV/Ii/GD/2014-422, respectively.

^fNucleotide identities are shown for genome. Amino acid identities are shown for other proteins. Method for nucleotide sequences analysis involved the bootstrap method with 100 replications with Kimura 2-parameter model; for amino acid sequences, the bootstrap method with 100 replications, JTT model, was used.

^gCounterparts to MERS-CoV S-RBD (accession number AFS88936, aa 367 to 588) through alignment.