Skip to main content
. Author manuscript; available in PMC: 2019 May 22.
Published in final edited form as: Biochemistry. 2018 May 10;57(20):2958–2970. doi: 10.1021/acs.biochem.8b00226

Figure 1.

Figure 1

(A) Hoogsteen H-bonding interactions between guanines in a G-tetrad and its graphical representation (guanine = blue diamond, K+ = gray sphere) assembling into a G4 structure. The double-headed arrows aligning the G-tetrads symbolize either intermolecular or intramolecular folding with undefined strand polarities. (B) The promoter region of the human NEIL3 gene containing a G-rich coding strand that may switch to an intramolecular G4 fold. Oligonucleotides including four (4-NEIL3) and five (5-NEIL3) G-tracks were analyzed in this study.