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. Author manuscript; available in PMC: 2019 Jun 11.
Published in final edited form as: Cancer Cell. 2018 Jun 11;33(6):1004–1016.e5. doi: 10.1016/j.ccell.2018.05.006

Figure 7. KCC-07 Inhibits Orthotopic MB Growth in mice xenografts.

Figure 7

(A) Kaplan-Meier survival curves show effect of KCC-07 (100 mg/kg i.p.; 5 days/week) on the survival of mice harboring D556 intracranial xenografts. p<0.0001, log-rank test.

(B) Effect of KCC-07 on tumor size (H&E), BAI1 and p53 expression (IHC) in tumors from (A). Scale bar in H&E images, 1 mm. Scale bar in IHC images, 25 µm.

(C) Kaplan-Meier survival curves shows effect of KCC-07 on the survival of mice harboring intracranial xenografts of D556 cells with lentiviral shRNA-mediated abrogation of BAI1 (p=0.16, log-rank test).

(D) Kaplan-Meier survival curves shows effect of KCC-07 on the survival of mice harboring intracranial xenografts of D556 cells with lentiviral shRNA-mediated abrogation of p53 (p=0.23, log-rank test).

See also Figure S6.