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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Sci Signal. 2018 May 15;11(530):eaaq1441. doi: 10.1126/scisignal.aaq1441

Figure 7. Model of regulatory feedback governing Aurora A, Plk1 and PP6.

Figure 7

(A) In G2, Aurora A and Plk1 activities are low and PP6R2-PP6c activity is high, serving as a check on premature Aurora A activation. (B) As cells enter mitosis, Aurora A is activated and PP6R2 is primed by the CDK1-cyclin B complex, promoting Plk1 activation and phosphorylation-dependent inhibition of PP6. This results in a net increase in Aurora A phosphorylation and activity. (C) At the onset of anaphase, protein turnover of cyclin B, Plk1 and Aurora A breaks this feedback loop and resets the PP6R2-PP6c complex for the subsequent cell cycle.