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. Author manuscript; available in PMC: 2019 Feb 7.
Published in final edited form as: Trends Genet. 2018 Feb 7;34(2):142–157. doi: 10.1016/j.tig.2017.11.005

Figure 3.

Figure 3

Model depicting potential mode of action of MALAT1. (A) MALAT1 along with MALAT1-interacting proteins such as unmethylated Pc2 relocates genomic loci from nucleoplasm or other nuclear domains to nuclear speckle periphery and promotes the activation of corresponding genes. (B) MALAT1 interacts with multiple chromatin modifiers and transcription factors to modulate transcription. (C) MALAT1 serves as a scaffold in nuclear speckles for RBPs and influences various co- and post-transcriptional processes.