Fig 3.

Examples of PC subjects without rim lesions, and “daughter lesions.” One PC subject with small-vessel disease (A, DIR; B, GM-DIR; C, T2 FLAIR; D, T1) shows typical juxtacortical and deep white matter lesions. Note the lack of rims around these lesions on GM-DIR. Another PC subject (E, DIR; F, GM-DIR) with neuromyelitis optica has a demyelinating corpus callosum lesion (open arrows) that also lacks a rim. One subject with MS (G, DIR; H, GM-DIR) shows typical conglomerate lesions on DIR imaging. GM-DIR imaging better demonstrates the separation and outline of smaller lesions (arrowheads) from larger lesions (arrows).