Table 4.

Associations between Hypomania Symptom Checklist-32 subscale scores in probands and lifetime mood disorders in relatives (N = 154)

	Mood disorders in relatives

	Bipolar I			Bipolar II			Major Depressive Disorder

	OR¹	95% CI	p-value	OR¹	95% CI	p-value	OR²	95% CI	p-value
PROBAND

HCL total	1.04²	[0.91–1.18]	0.583	0.99	[0.91–1.07]	0.775	1.03	[0.96–1.12]	0.412

HCL Activity/Increased energy	0.58	[0.40–0.83]	*0.003*	0.95	[0.73–1.23]	0.702	1.08	[0.82–1.41]	0.579
HCL Distractibility/Irritability	1.91	[1.32–2.78]	*0.001*	0.96	[0.72–1.29]	0.806	1.03	[0.79–1.33]	0.844
HCL Novelty seeking/Disinhibition	1.16	[0.68–1.97]	0.582	1.14	[0.78–1.68]	0.503	1.06	[0.74–1.51]	0.757
HCL Substance use	0.92	[0.31–2.71]	0.884	0.54	[0.10–2.99]	0.481	0.96	[0.42–2.21]	0.928
RELATIVE
Sex	1.94	[0.38–9.81]	0.424	0.57	[0.19–1.73]	0.318	2.98	[1.06–8.36]	*0.038*
Age	0.96	[0.92–1.01]	0.092	0.96	[0.93–0.99]	*0.012*	1.01	[0.98–1.03]	0.620

Abbreviation: OR, odds ratio; HCL, Hypomania Symptom Checklist-32.

Logistic regression model adjusted for sex and age in relatives.

Non-linear mixed model adjusted for sex and age in relatives.

Statistically significant results are in bold.

P-values are in italic.