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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2018 Apr 14;9(4):e1478. doi: 10.1002/wrna.1478

Figure 3. Exon skipping can be directly coupled to circular RNA production.

Figure 3

At the S. pombe mrps16 gene, exon skipping results in production of a mature linear mRNA as well as an intron lariat containing exon 2. This lariat is re-spliced to generate a mature circular RNA as well as a double lariat structure that is subsequently debranched and degraded.95