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(a, b) The charge clamp pocket in which SRC-1 (lavender) binds is located between K259 and E427 in hPXR (gray) (PDB 1NRL) (a) and between K177 and E355 in hCAR (brown) (PDB 1XVP) (b). (c) The structure of TCBOPOP-bound mCAR (silver) (PDB 1XLS) reveals a second charge clamp between R193 and E198 when the complex is bound to TIF2 (cyan).
