Fig. 3.

Antagonist of adenosine A1 receptor, DPCPX, prevents the actions of ethanol at lower concentrations but not at high concentrations. (A) Averaged EPSPs evoked in a layer 2/3 pyramidal neuron by paired-pulse stimuli (50-ms interpulse interval) in control, and through increasing ethanol concentrations. Time course of changes in the amplitude of individual EPSPs evoked by the first pulse in a pair (EPSP1, % of control). Specific antagonist of adenosine A1 receptor, DPCPX (30 nM) was present in the extracellular solution throughout the experiment. (B) Averaged changes in EPSP1 amplitude and PPR in n = 21 experiments with DPCPX. EPSP amplitudes were normalized by the amplitude of EPSP1 in control. Significance denoted as **P < 0.01; ***P < 0.001. Other conventions as in Fig. 2. [Colour figure can be viewed at wileyonlinelibrary.com].