Table 3.

Connectivity differences between rMDD and HC with default mode network seeds.

Seed with clustera	Network	Peak MNI coordinates	Cluster size (k)	Intensity (F)	gHedges		ICCb
					T1	T2	All	HC	rMDD
rMDD > HC
L-PCC Seed
R-SFG	DMN/SEN	8, 16, 62	168	21.03	0.69	0.82	0.65	0.62	0.56
L-MFG	CCN	−38, 44, 16	113	13.22	0.60	0.71	0.64	0.69	0.51
R-MFG	DMN/CCN	32, 32, 42	157	17.69	0.82	0.79	0.73	0.62	0.71
B-Prec	CCN	−2, −70, 46	334	16.30	0.78	0.94	0.66	0.66	0.50
R-PCC Seed
R-SFG	CCN	32, 10, 56	67	14.45	0.53	0.80	0.73	0.63	0.74
L-MFG	CCN	−38, 46, 16	173	13.38	0.58	0.66	0.73	0.83	0.53
R-MFG	CCN	42, 36, 22	556	21.37	0.85	0.90	0.73	0.80	0.49
L-IPL	CCN	−34, −58, 34	137	16.38	0.60	0.81	0.50	0.19	0.51
R-IPL	CCN	44, −52, 42	354	19.09	0.54	1.01	0.76	0.69	0.73
B-Prec	CCN	−4, −70, 44	332	19.76	0.77	0.81	0.70	0.69	0.60
rMDD < HC
R-PCC Seed
B-Prec	DMN	2, −52, 32	120	16.34	−0.68	−0.45	0.70	0.76	0.55
L-HPF Seed
R-STG	SMN/DMN	66, −34, 8	176	15.27	−0.77	−0.41	0.67	0.50	0.72
R-HPF Seed
R-mOFG	DMN	10, 60, −6	67	12.97	−0.75	−0.29	0.73	0.69	0.73
L-mOFG	DMN/SEN	−6, 56, −6	74	12.34	−0.53	−0.38	0.75	0.78	0.68
L-STG	SEN	−28, 14, −32	100	16.24	−0.80	−0.76	0.59	0.63	0.37
R-STG	SMN/DMN	68, −16, −2	219	22.25	−0.91	−0.42	0.72	0.68	0.70
R-Para	SMN	8, −42, 66	241	16.39	−0.97	−0.69	0.37	0.13	0.20

B, Bilateral; CCN, Cognitive Control Network; DMN, Default Mode Network; g_Hedges, unbiased Hedges g; HPF, Hippocampal Formation; ICC, Intraclass Correlation; IPL, Inferior Parietal Lobule; MFG, Middle Frontal Gyrus; mOFG, Medial Orbitofrontal Gyrus; Para, Paracentral Lobule; PCC, Posterior Cingulate Cortex; Prec, Precuneus; SEN, Salience Emotion Network; SFG, Superior Frontal Gyrus; SMN, Somatomotor Network; STG, Superior Temporal Gyrus.

^aAll reported clusters significant at p < 0.005, k > 57. Seed ROIs: radius, 2.9 mm; location, PCC ±5, −50, 36 and HPF ±30, −12, −18.

^bOne-way random, average measures, ICC (1, 2).