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. 2018 Jun 8;9:244. doi: 10.3389/fpsyt.2018.00244

Table 5.

Convergent validity, disease course and specificity of PCA connectivity components.

rMDD > HC rMDD < HC
Characteristica 1: Bilateral PCC with CCN 2: Right DMN with CCN/SEN 3: R-HPF with DMN 4: HPF with SMN 5: Bilateral PCC with DMN
CONVERGENT VALIDITY
RRS Total 0.19
[−0.05, 0.41]		 0.38**
[0.15, 0.57]		 −0.08
[−0.31, 0.16]		 −0.29*
[−0.49, −0.05]		 0.03
[−0.27, 0.27]
CC Factor −0.21†
[−0.42, 0.03]		 −0.12
[−0.34, 0.12]		 −0.13
[−0.35, 0.11]		 −0.13
[−0.35, 0.11]		 −0.08
[−0.31, 0.16]
SLLT d' −0.05
[−0.27, 0.17]		 −0.01
[−0.23, 0.21]		 0.23*
[0.01, 0.43]		 −0.05
[−0.27, 0.18]		 0.12
[−0.11, 0.33]
FEPT Happy Accuracyb 0.01
[−0.23, 0.24]		 −0.04
[−0.27, 0.19]		 −0.27*
[−0.47, −0.03]		 −0.24*
[−0.45, −0.01]		 −0.06
[−0.29, 0.18]
Sad Accuracy −0.03
[−0.26, 0.20]		 −0.11
[−0.33, 0.13]		 −0.02
[−0.25, 0.22]		 −0.10
[−0.32, 0.14]		 −0.17
[−0.38, 0.07]
DISEASE COURSE
HAM–D 0.24*
[0.02, 0.43]		 0.10
[−0.12, 0.31]		 0.06
[−0.16, 0.28]		 −0.30**
[−0.48, −0.09]		 0.04
[−0.18, 0.26]
Number of Episodesb −0.07
[−0.22, 0.35]		 −0.20
[−0.46, 0.09]		 −0.15
[−0.42, 0.15]		 0.09
[−0.21, 0.36]		 0.02
[−0.27, 0.30]
Age at Onsetb −0.09
[−0.37, 0.20]		 −0.07
[−0.35, 0.22]		 0.17
[−0.12, 0.44]		 0.08
[−0.22, 0.36]		 0.10
[−0.19, 0.38]
SPECIFICITY
Age 0.07
[−0.15, 0.28]		 0.11
[−0.11, 0.32]		 0.18
[−0.04, 0.38]		 0.07
[−0.15, 0.28]		 0.09
[−0.13, 0.30]
Verbal IQ −0.02
[−0.24, 0.20]		 0.01
[−0.21, 0.22]		 –0.26*
[−0.45, −0.04]		 –0.19†
[−0.39, 0.03]		 −0.13
[−0.34, 0.09]

PCA, Principle Components Analysis. Analyses included all subjects without missing data. Italics indicate a significant partial correlation after controlling for diagnosis (p < 0.05, one-tailed), which was only conducted following a significant initial correlation.

a

Some cognitive features and clinical variables were significantly correlated: verbal IQ was negatively related to SLLT d' (r = −0.25, p = 0.02), and residual HAM–D was positively related to both RRS total (r = 0.25, p = 0.04) and FEPT sad accuracy (r = 0.29, p = 0.01). No cognitive features were significantly correlated with each other.

b

Spearman's correlation ρ reported due to non-normal distribution.

†

p < 0.10,

*

p < 0.05,

**

p < 0.01, all two-tailed.