Table 6.

Current sample connectivity in regions implicated in active and familial risk for depression.

	Estimated marginal effects				Diagnosis effect
	HC		rMDD
Connectivity	M	SD	M	SD	Direction	F	p
ACTIVE DEPRESSION SUPERIOR FRONTAL GYRUS18
Left Dorsal Nexus from L–PCC	0.17	0.02	0.20	0.02	rMDD > HC	0.88	0.35
Right Dorsal Nexus from L-PCCb	0.15	0.02	0.16	0.02	rMDD > HC	0.05	0.82
Left Dorsal Nexus from R-PCCc	0.16	0.02	0.18	0.02	rMDD > HC	1.03	0.31
Right Dorsal Nexus from R-PCCb	0.21	0.02	0.22	0.02	rMDD > HC	0.01	0.91
FAMILIAL RISK FOR DEPRESSION MIDDLE FRONTAL GYRUS19
Left dlPFC from L-PCC	0.07	0.02	0.07	0.01	rMDD > HC	0.07	0.79
Right dlPFC from L-PCC	0.003	0.01	0.002	0.01	HC > rMDD	0.002	0.96
Left dlPFC from R-PCC	0.03	0.02	0.04	0.01	rMDD > HC	0.36	0.55
Right dlPFC from R-PCC	0.05	0.01	0.05	0.01	rMDD > HC	0.001	0.97
REMITTED DEPRESSION DORSOLATERAL PREFRONTAL CORTEX CLUSTERSa
Right SFG from L-PCC	0.03	0.03	0.17	0.02	rMDD > HC	19.50	<0.001
Left MFG from L-PCC	−0.08	0.02	0.04	0.02	rMDD > HC	14.90	<0.001
Right MFG from L-PCCd	0.12	0.03	0.26	0.02	rMDD > HC	17.14	<0.001
Right SFG from R-PCC	0.15	0.03	0.28	0.03	rMDD > HC	12.64	0.001
Left MFG from R-PCCc	−0.03	0.02	0.08	0.02	rMDD > HC	13.51	<0.001
Right MFG from R-PCC	0.05	0.02	0.18	0.02	rMDD > HC	24.41	<0.001

Estimated means, standard errors and significance determined using full linear mixed model with diagnosis, time, diagnosis by time, sex, and site as covariates.

^aCurrent study's diagnostic clusters near dorsolateral prefrontal cortex.

^bp < 0.05 for Site.

^cp < 0.05 for Sex.

^dp < 0.05 for Scan Session.